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:: Overview :: Precautions :: Side Effects :: Further Reading Search results last updated: 5/9/2009

Generic & Brand Name : Source: (RXList)

Brand Name : Zonegran
Generic Name : Zonisamide

Overview (Source: MedicineNet)
home > zonisamide-oral index > zonisamide-oral, zonegran drug monograph ...
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Precautions (Source: RXList)
Potentially Fatal Reactions to Sulfonamides: Fatalities have occurred, although rarely, as a result of severe reactions to sulfonamides (zonisamide is a sulfonamide) including Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic anemia, and other blood dyscrasias. Such reactions may occur when a sulfonamide is readministered irrespective of the route of administration. If signs of hypersensitivity or other serious reactions occur, discontinue zonisamide immediately. Specific experience with sulfonamide-type adverse reaction to zonisamide is described below. Serious Skin Reactions: Consideration should be given to discontinuing ZONEGRAN in patients who develop an otherwise unexplained rash. If the drug is not discontinued, patients should be observed frequently. Seven deaths from severe rash [i.e. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN)] were reported in the first 11 years of marketing in Japan. All of the patients were receiving other drugs in addition to zonisamide. In post-marketing experience from Japan, a total of 49 cases of SJS or TEN have been reported, a reporting rate of 46 per million patient-years of exposure. Although this rate is greater than background, it is probably an underestimate of the true incidence because of under-reporting. There were no confirmed cases of SJS or TEN in the US, European, or Japanese development programs. In the US and European randomized controlled trial ...
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Side Effects (Source: DrugDigest)
Side effects that you should report to your doctor or health care professional immediately: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue decreased sweating or a rise in body temperature, especially in patients under 17 years old depression difficulty breathing or tightening of the throat feeling faint or lightheaded, falls fever, sore throat, sores in your mouth, or bruising easily hallucination, loss of contact with reality irregular heartbeat loss of appetite redness, blistering, peeling or loosening of the skin, including inside the mouth severe drowsiness, difficulty concentrating, or coordination problems speech or language problems sudden back pain, abdominal pain, pain when urinating, bloody or dark urine unusually tired vomiting worsening of mood, thoughts or actions of suicide or dying Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): headache nausea This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. ...
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Further Reading on zonegran
  • Epilepsy - Treatment Overview ( WebMD )
    Treatment can reduce or prevent seizures in most people who have epilepsy , which can improve the quality of your life . Controlling ...Gabitril). Topiramate (Topamax). Zonisamide ( Zonegran ).

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