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:: Definition :: Images :: About :: Causes :: Symptoms :: Treatment :: Further Reading Search results last updated: 5/9/2009

zollinger-ellison syndrome - Definition: (Source: MedicineNet)

Zollinger-Ellison syndrome: A rare disorder caused by a tumor called a gastrinoma, most often occurring in the pancreas. The tumor secretes the hormone gastrin, which causes increased production of gastric acid leading to severe recurrent ulcers of the esophagus, stomach, and the upper portions of the small intestine (the duodenum and jejunum). ...
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zollinger-ellison syndrome - Images (Source: MedLinePlus)
zollinger-ellison syndrome, Endocrine glands
Endocrine glands

About zollinger-ellison syndrome (Source: MayoClinic)
Zollinger-Ellison syndrome is a complex condition in which one or more tumors form in your pancreas or in the upper part of your small intestine (duodenum). These tumors secrete large amounts of a hormone that causes excessive production of acid by your stomach. The excess acid, in turn, leads to peptic ulcers. ...
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eMedicineHealth Zollinger-Ellison syndrome

Causes of zollinger-ellison syndrome (Source: MedLinePlus)
Zollinger-Ellison syndrome is caused by tumors, usually found in the head of the pancreas and the upper small bowel. These tumors produce the hormone gastrin and are called gastrinomas. High levels of gastrin cause too much production of stomach acid. Gastrinomas occur as single tumors or as small, multiple tumors. About one-half to two-thirds of single gastrinomas are cancerous (malignant) tumors that commonly spread to the liver and nearby lymph nodes. A number of patients with gastrinomas have many tumors as part of a condition called multiple endocrine neoplasia type I (MEN I). MEN I patients often have tumors of the pituitary gland (brain) and parathyroid gland (neck), as well as tumors of the pancreas. ...
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Symptoms of zollinger-ellison syndrome (Source: MedLinePlus)
Abdominal pain ; Diarrhea ; Ulcers in the stomach and small bowel; Vomiting blood (occasional). ...
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zollinger-ellison syndrome - Conventional Treatments (Source: MedLinePlus)
Medications called proton pump inhibitors (omeprazole, lansoprazole) are now the first choice for treating Zollinger-Ellison syndrome. These drugs reduce acid production by the stomach, and promote healing of ulcers in the stomach and small bowel. They also relieve abdominal pain and diarrhea. Surgery to remove a single gastrinoma may be done if there is no evidence that it has spread to other organs (such as lymph nodes or the liver). Surgery on the stomach (gastrectomy) to control acid production is rarely needed today. ...
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Further Reading on zollinger-ellison syndrome
  • Gastrin ( WebMD )
    A gastrin test measures the level of the hormone gastrin in the blood . Gastrin is produced by cells ...tumors of the pancreas or small intestine ( Zollinger - Ellison syndrome ) or abnormal growth of...
  • Syndrome, Zollinger-Ellison ( MedicineNet )
  • Syndrome, Zollinger-Ellison ( eMedicineHealth )

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