Adverse experiences following the administration of lidocaine are similar in nature to those observed with other amide local anesthetic agents. These adverse experiences are, in general, dose-related and may result from high plasma levels caused by overdosage, rapid absorption, or inadvertent intravascular injection, or may result from a hypersensitivity, idiosyncrasy or diminished tolerance on the part of the patient. Table 1: Adverse Drug Reaction Frequencies Common ( > 1/100 Vascular disorders: hypotension, hypertension Gastrointestinal disorders: nausea, vomiting Nervous system disorders: parethesia, dizziness Cardiac disorders: bradycardia Uncommon ( > 1/1,000 Nervous system disorders: Signs and symptoms of CNS toxicity (convulsions, paresthesia circumoral, numbness of the tongue, hyperacusis, visual disturbances, tremor, tinnitus, dysarthria, CNS depression) Rare( Cardiac disorders: cardiac arrest, cardiac arrhythmias Immune system disorders: allergic reactions, anaphylactic reaction/shock Respiratory disorders: respiratory depression Nervous system disorders: neuropathy, peripheral nerve injury, arachnoiditis Eye disorders: diplopia Serious adverse experiences are generally systemic in nature. The following types are those most commonly reported: Central Nervous System CNS manifestations are excitatory and/or depressant and may be characterized by circumoral paresthesia, lightheadedness, nervousness, apprehension, euphoria, confusion, dizziness, drowsiness, hyperacusis
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