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:: Overview :: Precautions :: Side Effects :: Further Reading Search results last updated: 5/9/2009

Generic & Brand Name : Source: (RXList)

Brand Name : Xeloda
Generic Name : Capecitabine

Overview (Source: MedicineNet)
Capecitabine is an oral medication for treating advanced breast cancers that are resistant to combination therapy with the drugs of choice, paclitaxel (Taxol) and a drug from the anthracycline family of drugs, for example, doxorubicin (Adriamycin). Capecitabine is converted by the body to 5-fluorouracil (5-FU), a drug which has been given intravenously for many years to treat various types of cancer . It is not surprising, therefore, that capecitabine also is effective in the treatment of colorectal cancer, a type of cancer which is treated frequently with 5-FU. 5-FU inhibits the production of both DNA and protein by the cancerous cells that are necessary for the cells to divide and the cancer to grow in size. Capecitabine was approved by the FDA in 1998 for the treatment of breast cancer and in 2005 for the treatment of colorectal cancer. ...
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Precautions (Source: RXList)
Renal Insufficiency Patients with moderate renal impairment at baseline require dose reduction (see DOSAGE AND ADMINISTRATION ). Patients with mild and moderate renal impairment at baseline should be carefully monitored for adverse events. Prompt interruption of therapy with subsequent dose adjustments is recommended if a patient develops a grade 2 to 4 adverse event as outlined in Table 18 in DOSAGE AND ADMINISTRATION . Coagulopathy See BOXED WARNING . Diarrhea XELODA can induce diarrhea, sometimes severe. Patients with severe diarrhea should be carefully monitored and given fluid and electrolyte replacement if they become dehydrated. In 875 patients with either metastatic breast or colorectal cancer who received XELODA monotherapy, the median time to first occurrence of grade 2 to 4 diarrhea was 34 days (range from 1 to 369 days). The median duration of grade 3 to 4 diarrhea was 5 days. National Cancer Institute of Canada (NCIC) grade 2 diarrhea is defined as an increase of 4 to 6 stools/day or nocturnal stools, grade 3 diarrhea as an increase of 7 to 9 stools/day or incontinence and malabsorption , and grade 4 diarrhea as an increase of ≥ 10 stools/day or grossly bloody diarrhea or the need for parenteral support. If grade 2, 3 or 4 diarrhea occurs, administration of XELODA should be immediately interrupted until the diarrhea resolves or decreases in intensity to grade 1. Following a reoccurrence of grade 2 diarrhea or occurrence of any grade 3 or 4 diarrhea, subsequent do ...
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Side Effects (Source: DrugDigest)
Side effects that you should report to your doctor or health care professional as soon as possible: allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue low blood counts - this medicine may decrease the number of white blood cells, red blood cells and platelets. You may be at increased risk for infections and bleeding. signs of infection - fever or chills, cough, sore throat, pain or difficulty passing urine signs of decreased platelets or bleeding - bruising, pinpoint red spots on the skin, black, tarry stools, blood in the urine signs of decreased red blood cells - unusually weak or tired, fainting spells, lightheadedness breathing problems changes in vision chest pain diarrhea of more than 4 bowel movements in one day or any diarrhea at night mouth sores nausea and vomiting pain, swelling, redness at site where injected pain, tingling, numbness in the hands or feet redness, swelling, or sores on hands or feet stomach pain vomiting yellow color of skin or eyes Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome): constipation diarrhea dry or itchy skin hair loss loss of appetite nausea weak or tired This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. ...
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Further Reading on xeloda
  • Rectal Cancer ( WebMD )
    Rectal cancer is cancer of the rectum , the lower part of the colon that connects the large bowel to ...pain in the palms of the hands and the soles of the feet). Capecitabine ( Xeloda ): This drug is...

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