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tay-sachs disease - Definition: (Source: MedicineNet)

Sandhoff disease: A genetic disorder with symptoms that are very similar to those of Tay-Sachs disease (TSD) and that is characterized by accumulation of fatty material called GM2 ganglioside in the nerve cells of the brain. Symptoms begin around 6 months of age, with motor weakness, and progress to include difficulties with swallowing and breathing. Death usually occurs by age 3. Sandhoff disease is an autosomal recessive disorder caused by a mutation to chromosome 5. Unlike TSD, it is most common in the non-Jewish population. See also Tay-Sachs disease. ...
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Hotlines for tay-sachs disease (Source: HealthHotLines)
National Tay-Sachs and Allied Diseases Association
(800) 90-NTSAD (906-8723)


About tay-sachs disease (Source: Medem)
Tay-Sachs disease is a fatal genetic lipid storage disorder in which harmful quantities of a fatty substance called ganglioside GM2 build up in tissues and nerve cells in the brain. The condition is caused by insufficient activity of an enzyme called beta-hexosaminidase A that catalyzes the biodegradation of acidic fatty materials known as gangliosides. Gangliosides are made and biodegraded rapidly in early life as the brain develops. ...
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Symptoms of tay-sachs disease (Source: MedLinePlus)
Deafness ; Decreased eye contact, blindness ; Decreased muscle tone (loss of muscle strength); Delayed mental and social skills; Dementia ; Increased startle reaction; Irritability; Listlessness; Loss of motor skills; Paralysis or loss of muscle function; Seizures ; Slow growth. ...
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Get A Second Opinion From...
HealthAtoZ tay-sachs disease
NHSDirect tay-sachs disease
HealthEncyclopaedia tay-sachs disease

Further Reading on tay-sachs disease
  • Tay - Sachs Disease - Treatment Overview ( WebMD )
    There is no cure for Tay - Sachs disease . Treatment, such as seizure medication, is aimed at controlling symptoms.
  • Tay - Sachs Disease - Topic Overview ( WebMD )
    Tay - Sachs disease is a rare genetic disorder in which little or no hexosaminidase A (hex A) enzyme is produced by the body.
  • Tay - Sachs Test ( WebMD )
    The test for Tay - Sachs disease measures the amount of an enzyme called hexosaminidase A in the blood.
  • Amniocentesis ( WebMD )
    Amniocentesis is a test to look at the fluid ( amniotic fluid ) that surrounds your baby ( fetus )...father are known carriers of a family disease , such as Tay - Sachs disease , sickle cell anemia,
  • Chorionic Villus Sampling (CVS) ( WebMD )
    Chorionic villus sampling ( CVS ) is a test done during early pregnancy that can find certain problems ...either you or the father has a disease that runs in the family (genetic disorder...used to...


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