The following adverse reactions are discussed in greater detail in other sections of the label. Increased susceptibility to infection , lymphoma , and malignancy [see Boxed Warning , WARNINGS AND PRECAUTIONS ] Excess mortality , graft loss, and hepatic artery thrombosis in liver transplant patients [see Boxed Warning , WARNINGS AND PRECAUTIONS ] Bronchial anastomotic dehiscence in lung transplant patients [see Boxed Warning , WARNINGS AND PRECAUTIONS ] Hypersensitivity reactions [see WARNINGS AND PRECAUTIONS ] Exfoliative dermatitis [see WARNINGS AND PRECAUTIONS ] Angioedema [see WARNINGS AND PRECAUTIONS ] Fluid Accumulation and Wound Healing [see WARNINGS AND PRECAUTIONS ] Hypertriglyceridemia, hypercholesterolemia [see WARNINGS AND PRECAUTIONS ] Decline in renal function in long-term combination of cyclosporin with Rapamune [see WARNINGS AND PRECAUTIONS ] Proteinuria [see WARNINGS AND PRECAUTIONS ] Interstitial lung disease [see WARNINGS AND PRECAUTIONS ] Increased risk of calcineurin inhibitor-induced hemolytic uremic syndrome/thrombotic thrombocytopenic purpura/thrombotic microangiopathy (HUS/TTP/TMA) [see WARNINGS AND PRECAUTIONS ]. The most common ( ≥ 30%) adverse reactions observed with Rapamune in clinical studies are: peripheral edema , hypertriglyceridemia, hypertension , hypercholesterolemia, creatinine increased, constipation , abdominal pain , diarrhea , headache , fever , urinary tract infection , anemia , nausea , arthralgia , pain , and thrombocytopenia . The
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