Injury: Crushing the base of the nail or the nail bed may cause a permanent deformity. Chronic picking or rubbing of the skin behind the nail can cause a washboard nail. Long-term use exposure to moisture or nail polish can cause nails to peel and become brittle. Infection: Fungus or yeast cause changes in the color, texture, and shape of the nails. Bacterial infection may cause a change in nail color or painful areas of infection under the nail or in the surrounding skin. Severe infections may cause nail loss. Viral warts may cause a change in the shape of the nail or ingrown skin under the nail. Certain infections (especially of the heart valve) may cause splinter hemorrhages (red streaks in the nail bed). Diseases: Disorders that affect the amount of oxygen in the blood (such as abnormal heart anatomy and lung diseases including cancer or infection) may cause clubbing . Kidney disease can causes a build-up of nitrogen waste products in the blood, which can damage nails. Liver disease can damage nails. Thyroid diseases including hyperthyroidism or hypothyroidism may cause brittle nails or splitting of the nail bed from the nail plate (onycholysis). Severe illness or surgery may cause horizontal depressions in the nails (Beau's lines). Psoriasis may cause pitting, splitting of nail plate from nail bed (onycholysis), and chronic destruction of the nail plate (nail dystrophy); Other conditions that can affect the appearance of nails include systemic amyloidosis , malnutrition
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