The first therapy tried is usually a steroid medication, such as prednisone. If steroid medications do not improve the condition, removal of the spleen ( splenectomy ) may be considered. Immunosuppressive therapy is usually given if the person does not respond to steroids and splenectomy. Medications such as Azathioprine (Imuran), cyclophosphamide (Cytoxan), and rituximab (Rituxan) have been used. Blood transfusions are given with caution, because of the potential that blood may not be compatible and may cause further hemolysis.
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