Infants or children that fail to thrive seem to be dramatically smaller or shorter than other children the same age. Teenagers may have short stature or appear to lack the usual changes that occur at puberty. However, there is a wide variation in normal growth and development . In general, the rate of change in weight and height may be more important than the actual measurements. It is important to determine whether failure to thrive results from medical problems or factors in the environment, such as abuse or neglect. There are multiple medical causes of failure to thrive. These include: Chromosome abnormalities such as Down syndrome and Turner syndrome ; Defects in major organ systems; Problems with the endocrine system, such as thyroid hormone deficiency, growth hormone deficiency, or other hormone deficiencies; Damage to the brain or central nervous system, which may cause feeding difficulties in an infant; Heart or lung problems, which can affect how oxygen and nutrients move through the body; Anemia or other blood disorders; Gastrointestinal problems that result in malabsorption or a lack of digestive enzymes; Long-term gastroenteritis and gastroesophageal reflux (usually temporary); Cerebral palsy ; Long-term (chronic) infections; Metabolic disorders; Complications of pregnancy and low birth weight. Other factors that may lead to failure to thrive: Emotional deprivation as a result of parental withdrawal, rejection, or hostility; Economic problems that affect nutritio
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